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Bone marrow absorbed dose estimates as derived either using S values (SMIRD), Monte Carlo simulations under the assumption of a physiological active bone marrow distribution (MC1), or Monte Carlo simulations assuming no active bone marrow at the direct location of the bone lesions (MC2)
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Bone marrow absorbed dose estimates as derived either using S values (SMIRD), Monte Carlo simulations under the assumption of a physiological active bone marrow distribution (MC1), or Monte Carlo simulations assuming no active bone marrow at the direct location of the bone lesions (MC2)
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Bone marrow absorbed dose estimates as derived either using S values (SMIRD), Monte Carlo simulations under the assumption of a physiological active bone marrow distribution (MC1), or Monte Carlo simulations assuming no active bone marrow at the direct location of the bone lesions (MC2)
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Bone marrow absorbed dose estimates as derived either using S values (SMIRD), Monte Carlo simulations under the assumption of a physiological active bone marrow distribution (MC1), or Monte Carlo simulations assuming no active bone marrow at the direct location of the bone lesions (MC2)
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Bone marrow absorbed dose estimates as derived either using S values (SMIRD), Monte Carlo simulations under the assumption of a physiological active bone marrow distribution (MC1), or Monte Carlo simulations assuming no active bone marrow at the direct location of the bone lesions (MC2)
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Bone marrow absorbed dose estimates as derived either using S values (SMIRD), Monte Carlo simulations under the assumption of a physiological active bone marrow distribution (MC1), or Monte Carlo simulations assuming no active bone marrow at the direct location of the bone lesions (MC2)

Journal: EJNMMI Research

Article Title: 3D Monte Carlo bone marrow dosimetry for Lu-177-PSMA therapy with guidance of non-invasive 3D localization of active bone marrow via Tc-99m-anti-granulocyte antibody SPECT/CT

doi: 10.1186/s13550-019-0548-z

Figure Lengend Snippet: Bone marrow absorbed dose estimates as derived either using S values (SMIRD), Monte Carlo simulations under the assumption of a physiological active bone marrow distribution (MC1), or Monte Carlo simulations assuming no active bone marrow at the direct location of the bone lesions (MC2)

Article Snippet: Bone marrow dosimetry estimates derived from the bone marrow models MC1, MC2, and SMIRD were compared among each other, and respective differences were further correlated with the bone lesion load, the time-integrated tumor uptake, and the time-integrated ROB retention (MATLAB Pearson’s correlation), to estimate which influencing factors of absorbed dose modeling define differences between the investigated models.

Techniques: Derivative Assay, Activity Assay